There have been significant changes in transportation over the last few years and substantial change is expected in the near future. The application of advanced technologies and the availability of a tremendous amount of real-time data “Big Data” is expected to completely change the ways in which transportation systems are designed, built, operated and maintained. One particular area that can benefit significantly from the application of advanced technologies is road safety. The importance of reducing the social and economic costs of road accidents cannot be overstated as 1.35 million people are killed annually in road crashes and many more are severely injured. The application of innovations that are both progressing and disrupting the status quo represents an opportunity for improved transportation safety. However, with the introduction of new modes of mobility and the complex interactions created by these different technologies within the transportation system, governments will need to rely on advanced research and analysis techniques to support policies towards the transition to these new forms of mobility. Several methods and techniques developed in this area will be described with example projects from several agencies worldwide.